| Autor: |
M, Loriga, M, Fiore, P, Sanna, G, Paglietti |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Farmaco (Societa chimica italiana : 1989). 50(5) |
| ISSN: |
0014-827X |
| Popis: |
Thirty-five quinoxalines bearing a substituted aniline group on position 2 and various substituents on positions 3,6,7 and 8 were prepared in order to evaluate in vitro anticancer activity. Structural elucidation of some isomeric quinoxalinones formed by ring closure of 4-substituted-1,2-diaminobenzenes with dicarbonyl compounds was achieved by comparison with one isomer coming from an unambiguous independent route. Preliminary in vitro screening at NCI showed that many compounds exhibited a moderate to strong growth inhibition activity on various cell lines between 10(-5) and 10(-4) molar concentrations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
