| Autor: |
G W, Chan, S, Mong, M E, Hemling, A J, Freyer, P H, Offen, C W, DeBrosse, H M, Sarau, J W, Westley |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Journal of natural products. 56(1) |
| ISSN: |
0163-3864 |
| Popis: |
Three new imidazole alkaloids, leucettamines A [1] and B [2] and leucettamidine [3], have been isolated from the Palauan sponge Leucetta microraphis. Their structures were established on the basis of extensive spectral analyses. Leucettamine A showed potent leukotriene B4 receptor binding activity (K(i) = 1.3 microM), while leucettamine B was essentially inactive (K(i) = 100 microM) and leucettamidine showed significant activity (K(i) = 5.3 microM). With leucettamine A identified as a pure LTB4 receptor antagonist, a new structure lead is presented to inflammation therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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