| Autor: |
Bao-Qiang, Song, Kai-Hua, Lu, Shu-Zhong, Guo, Yang, Zhang, Pai, Peng, Fu-Cheng, Ma, Hui-Yuan, Li |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. 24(2) |
| ISSN: |
1009-4598 |
| Popis: |
To investigate the effect of METH1 gene transfection on fibroblast proliferation and I, III collagen synthesis in rabbit ear scar.The hypertrophic scar model on the rabbit ears was reproduced. 10 days after epithelization, Ad-METH1 was injected into the scar tissue. 30 days later, the effect of METH1 gene transfection on the angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue was detected by microcirculation microscope, AgNOR particle count and collagen dyeing.30 days after injection of Ad-METH1, angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue were obviously suppressed.Early application of Ad-METH1 after epithelization can markedly inhibit the formation of the hypertrophic scar. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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