| Autor: |
Geffner, J R, Serebrinsky, G, Isturiz, M A |
| Jazyk: |
angličtina |
| Rok vydání: |
1986 |
| Předmět: |
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| Popis: |
A progressive inhibition of both antibody-dependent cellular cytotoxicity (ADCC) and Fc gamma R expression was observed when peripheral blood mononuclear cells (PBMC) were incubated with soluble immune complexes (IC) at 37 degrees. Treatment of these IC-blocked PBMC with normal human serum (NHS) reversed both effects and increased the release of attached IC from the cell surface when compared to heat-inactivated serum (HI-NHS) or culture medium (TCM) treatments. Immunofluorescence studies demonstrated a redistribution of IC, predominantly in the form of caps in IC-blocked cells treated with HI-NHS (56%) or TCM (51%). However, when these IC-blocked cells were treated with NHS, only 11% of them showed caps redistribution. We propose that NHS regulation of Fc gamma R expression may be a physiological way of modulating the different immunological events triggered by IC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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