Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4
| Autor: | Marta, Szandruk-Bender, Benita, Wiatrak, Stanisław, Dzimira, Anna, Merwid-Ląd, Łukasz, Szczukowski, Piotr, Świątek, Adam, Szeląg |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
STAT3 Transcription Factor
Oxadiazoles Interleukin-6 Tumor Necrosis Factor-alpha Prostaglandins E Interleukin-17 Nuclear Receptor Subfamily 1 Group F Member 3 Colitis Inflammatory Bowel Diseases Interleukin-23 T-Lymphocytes Regulatory Rats Disease Models Animal Trinitrobenzenesulfonic Acid Animals Cytokines Th17 Cells |
| Zdroj: | International journal of molecular sciences. 23(17) |
| ISSN: | 1422-0067 |
| Popis: | The pharmacotherapy of inflammatory bowel disease (IBD) is still not fully effective and safe. Attempts to search for new IBD drugs remain an incessant research aim. One of the novel approaches is targeting the developmental pathway molecules and effector cytokines of Th17/Treg axis. This study aimed to elucidate the impact of new pyrrolo[3,4 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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