Prevalence and molecular characterization of G1P[8] human rotaviruses possessing DS-1-like VP6, NSP4, and NSP5/6 in Japan

Autor:	Mitsutaka, Kuzuya, Ritsushi, Fujii, Masako, Hamano, Koji, Kida, Yoshinori, Mizoguchi, Tomohisa, Kanadani, Keiko, Nishimura, Toshio, Kishimoto
Rok vydání:	2013
Předmět:	Male Rotavirus Molecular Epidemiology Adolescent Genotype Molecular Sequence Data Genetic Variation Infant Sequence Analysis DNA Viral Nonstructural Proteins Rotavirus Infections Japan Child Preschool Prevalence Humans RNA Viral Capsid Proteins Female Child Antigens Viral
Zdroj:	Journal of medical virology. 86(6)
ISSN:	1096-9071
Popis:	During a survey of human rotaviruses in Okayama Prefecture, Japan in the 2011-2012 rotavirus season (between September 2011 and August 2012), G3P[8] was found to be a predominant genotype overall. However, G1P[8] emerged in the latter half of the season. To clarify the genetic background of the G1P[8] strains, the VP7, VP4, VP6, NSP4, and NSP5/6 genes of the strains were sequenced and genotyped. As a result, it was demonstrated that the strains with two different genotype constellations (G1-P[8]-I1-E1-H1 and G1-P[8]-I2-E2-H2) prevailed in the season. The G1P[8] strains possessing the DS-1-like VP6, NSP4, and NSP5/6 genes (the DS-1-like G1P[8] strains), which should reveal a short electropherotype, were originated from possible intergenogroup reassortment events. The DS-1-like G1P[8] strains accounted for 74.1% of all G1P[8] strains and were detected continuously throughout the season but not in the preceding season, indicating the possibility of new introduction and rapid spreading of these strains in the 2011-2012 season. The results suggest that the intergenogroup reassortants, considered generally unstable, can spread rapidly and become relevant.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bce4de19ac9c46ee5f4247159ae5686e https://pubmed.ncbi.nlm.nih.gov/24105775 Zobrazit plný text záznamu Plný text