| Autor: |
Christian Østergaard, Mariager, Esben Søvsø Szocska, Hansen, Sabrina Kahina, Bech, Anders, Munk, Uffe, Kjaergaard, Mads Dam, Lyhne, Karsten, Søberg, Peter Fast, Nielsen, Steffen, Ringgaard, Christoffer, Laustsen |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Magnetic resonance in medicineREFERENCES. 84(5) |
| ISSN: |
1522-2594 |
| Popis: |
Normothermic perfusion is an emerging strategy for donor organ preservation and therapy, incited by the high worldwide demand for organs for transplantation. Hyperpolarized MRI and MRS using [1-Kidneys from four 40-kg Danish domestic pigs were perfused ex vivo with whole blood under normothermic conditions, using an MR-compatible perfusion system. Kidneys were investigated usingFour kidneys were successfully perfused for 120 minutes and verified using a DCE perfusion experiment. Renal metabolism was examined using hyperpolarized [1-This study demonstrates the ability to monitor ex vivo graft metabolism and function in a large animal model, resembling human renal physiology. The ability of hyperpolarized MRI and MRS to directly compare the metabolic state of an organ in vivo and ex vivo, in combination with the simple MR implementation of normothermic perfusion, renders this methodology a powerful future tool for graft preservation research. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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