[Potential neurotoxicity of general anaesthetics to the developing brain]

Autor: Nicola G, Clausen, Søren, Venø, Mads, Astvad, Steen W, Henneberg, Kaare, Christensen, Tom G, Hansen
Rok vydání: 2014
Předmět:
Zdroj: Ugeskrift for laeger. 176(34)
ISSN: 1603-6824
Popis: Animal studies (including non-human primates) have shown that most general anaesthetics cause enhanced neuroapoptosis with subsequent long-term neurocognitive deficits later in life. Some human cohort studies have indicated an association between anaesthesia/surgery and adverse neurocognitive outcome whereas other studies have not. Overall, the data do not justify any change in paediatric anaesthetic clinical practice. Naturally, the risks and benefits of a procedure should always be carefully considered before exposing a child to general anaesthesia.
Databáze: OpenAIRE