| Autor: |
C E, Gallenga, F, Pandolfi, Al, Caraffa, S K, Kritas, G, Ronconi, E, Toniato, S, Martinotti, P, Conti |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of biological regulators and homeostatic agents. 33(1) |
| ISSN: |
0393-974X |
| Popis: |
Activated mast cells (MCs) secrete a number of compounds including pro-inflammatory and anti-inflammatory cytokines. MCs are a potential source of cytokines and chemokines which participate in allergic reactions and inflammation. MCs can be activated by IgE through its receptor FceRI, but also by Toll-like receptors and/or interleukin (IL)-1. MCs can be a target for both pro-inflammatory and anti-inflammatory cytokines. IL-1 activates MCs to release inflammatory chemical mediators, and cytokines/chemokines, an effect which can be potentially inhibited by IL-37. In addition, IL-36 is also a powerful cytokine with a pro-inflammatory activity. IL-38 binds IL-36R and inhibits the pro-inflammatory activity of IL-36, thus performing a therapeutic action. In this article we review the role of MCs in relation to pro-inflammatory and anti-inflammatory IL-1 family member cytokines and a possible therapeutic effect in inflammatory disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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