Choroid plexus-selective inactivation of adenosine A

Autor:	Wu, Zheng, Yijia, Feng, Zhenhai, Zeng, Mengqian, Ye, Mengru, Wang, Xin, Liu, Ping, Tang, Huiping, Shang, Xiaoting, Sun, Xiangxiang, Lin, Muran, Wang, Zhengzheng, Li, Yiyun, Weng, Wei, Guo, Sergii, Vakal, Jiang-Fan, Chen
Rok vydání:	2021
Předmět:	Mice Inbred C57BL Mice Adenosine Encephalomyelitis Autoimmune Experimental Receptor Adenosine A2A Choroid Plexus Animals
Zdroj:	Journal of neuroinflammation. 19(1)
ISSN:	1742-2094
Popis:	Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by the infiltration of immune cells into the brain and demyelination. The unwanted immunosuppressive side effect of therapeutically successful natalizumab led us to focus on the choroid plexus (CP), a key site for the first wave of immune cell infiltration in experimental autoimmune encephalomyelitis (EAE), for the control of immune cells trafficking. Adenosine AIn the EAE model, we assessed AWe found the specific upregulation of AThese findings define the CP niche as one of the primary sites of A
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bca078ea6fdb5a6e207e5ec2439ad509 https://pubmed.ncbi.nlm.nih.gov/35180864 Zobrazit plný text záznamu Full text from SpringerLink