Cell adhesion is regulated by CDK1 during the cell cycle

Autor:	Matthew C, Jones, Janet A, Askari, Jonathan D, Humphries, Martin J, Humphries
Rok vydání:	2018
Předmět:	genetic structures Mitosis environment and public health enzymes and coenzymes (carbohydrates) Actin Cytoskeleton Cell Line Tumor Commentaries CDC2 Protein Kinase Cell Adhesion Humans biological phenomena cell phenomena and immunity Cyclin B1 Phosphorylation Spotlight Cyclin A2 HeLa Cells
Zdroj:	The Journal of Cell Biology
ISSN:	1540-8140
Popis:	Zaidel-Bar introduces work by Jones et al. demonstrating how adhesion is regulated during the cell cycle by CDK1. Adherent cells round up before division but it is unclear how detachment is regulated by the cell cycle. In this issue, Jones et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201802088) find the kinase CDK1 maintains adhesion during interphase by phosphorylating integrin adhesome proteins, including the formin FMNL2, and loss of this function of CDK1 activity in G2 triggers adhesion disassembly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bc942122726e7970fc487c65ef8955f1 https://pubmed.ncbi.nlm.nih.gov/30115667 Zobrazit plný text záznamu