An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide. synthesis and preliminary biological studies

Autor:	K L, Weiss, G, Alshafie, J S, Chapman, S M, Mershon, H, Abou-Issa, M, Clagett-Dame, R W, Curley
Rok vydání:	2001
Předmět:	Fenretinide Hydrolysis Animals Mammary Neoplasms Experimental Antineoplastic Agents Female Vitamin A Biotransformation Rats
Zdroj:	Bioorganicmedicinal chemistry letters. 11(12)
ISSN:	0960-894X
Popis:	The synthesis of a nonhydrolyzable, carbon-linked analogue (4-HBR) of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) using Umpolung methods is described. Preliminary studies of biological activity show 4-HBR is similar to 4-HPR in its actions although a potentially relevant and desirable difference is its reduced suppression of plasma vitamin A levels. These results show that 4-HPR does not have to be hydrolyzed to retinoic acid to produce its chemotherapeutic effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bc7333b3a1126bcc2ac03d2e33d96f66 https://pubmed.ncbi.nlm.nih.gov/11412986 Zobrazit plný text záznamu Full Text from ScienceDirect