The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line
| Autor: | M S, Myer, G, Joone, M R, Chasen, C E, van Rensburg |
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| Rok vydání: | 1998 |
| Předmět: |
Lung Neoplasms
Molecular Structure Paclitaxel Daunorubicin Vinorelbine Docetaxel Isoquinolines Vinblastine Drug Resistance Multiple Neoplasm Proteins Drug Resistance Neoplasm Tetrahydroisoquinolines Tumor Cells Cultured Acridines Humans Taxoids ATP Binding Cassette Transporter Subfamily B Member 1 Carcinoma Small Cell Cell Division Etoposide |
| Zdroj: | Oncology reports. 6(1) |
| ISSN: | 1021-335X |
| Popis: | GF120918, at 250 ng/ml, increased the sensitivity of a P-glycoprotein (P-gp)-mediated multidrug resistant (MDR) small cell lung cancer cell line (H69/LX4) to the P-gp substrates, paclitaxel, taxotere, vinblastine, vinorelbine, daunorubicin and etoposide to levels which were either greater (in the case of etoposide) or close to that of the parent cell line (H69/P). This was achieved in spite of the great variation in the levels of resistance of the MDR cell line for the various anti-cancer drugs tested. These data suggest that GF120918 is a potent antagonist of P-gp mediated multidrug resistance, even in the case of high levels of resistance, as was the case with paclitaxel and taxotere (2560 and 2215 fold more than the sensitive parent cell line respectively). |
| Databáze: | OpenAIRE |
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