Serum pepsinogen and gastrin levels in HIV-positive patients: relationship with CD4+ cell count and Helicobacter pylori infection

Autor:	P, Fabris, A, Pilotto, L, Bozzola, G, Tositti, G, Soffiati, V, Manfrin, F, de Lalla
Rok vydání:	2002
Předmět:	Adult Male Acquired Immunodeficiency Syndrome AIDS-Related Opportunistic Infections Helicobacter pylori Middle Aged CD4 Lymphocyte Count Helicobacter Infections Parietal Cells Gastric Gastritis Gastrins Pepsinogen C Humans Female Autoantibodies
Zdroj:	Alimentary pharmacologytherapeutics. 16(4)
ISSN:	0269-2813
Popis:	The relationship between serum parameters of gastric function and Helicobacter pylori infection in human immunodeficiency virus (HIV)-positive patients is almost unknown.To investigate in HIV-infected patients: (i) the relationship between serum gastrin and serum pepsinogens over the progressive phases of HIV-related disease; (ii) the impact of H. pylori infection on gastrin and pepsinogen serum levels and its relation to antral histology; (iii) the prevalence of parietal cell autoantibodies.Fifty-nine HIV-positive patients were studied by upper endoscopy plus gastric antral biopsy. Serum samples were tested for gastrin, pepsinogen A, pepsinogen C and parietal cell autoantibodies.In patients without overt acquired immunodeficiency syndrome (AIDS), or with a CD4+ count of100 x 10(6) cells/L, mean serum levels of gastrin and pepsinogen C were higher than in subjects with AIDS or with a CD4+ count of100 x 10(6) cells/L (P0.01). Only one patient was found to be positive for parietal cell autoantibodies. H. pylori infection was associated with increased values of gastrin and pepsinogen C only in HIV-positive patients without AIDS or with a CD4+ count of100 x 10(6) cells/L. Atrophy was more frequent in patients with overt AIDS than in those without overt AIDS (57% vs. 33%, P=N.S.), and/or in patients with a CD4+ count of100 x 10(6) cells/L than in those with a CD4+ count of100 x 10(6) cells/L (62% vs. 26%, P0.05).HIV-positive patients without overt AIDS have increased serum levels of gastrin and pepsinogen C compared with HIV-positive patients with overt AIDS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bc25f99a8f2445c44bfbec07e21f0c45 https://pubmed.ncbi.nlm.nih.gov/11929400 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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