| Autor: |
M E A, Rath, V E H J, Smits-Wintjens, D, Oepkes, E W, van Zwet, I L, van Kamp, A, Brand, F J, Walther, E, Lopriore |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Vox sanguinis. 102(3) |
| ISSN: |
1423-0410 |
| Popis: |
To evaluate the incidence and severity of and risk factors for thrombocytopenia at birth in neonates with red cell alloimmunization.All neonates with haemolytic disease of the foetus/newborn (HDFN) due to red cell alloimmunization admitted to our centre between January 2000 and September 2010 were included in this retrospective study. We measured platelet counts at birth and determined the incidence of thrombocytopenia (platelet count150×10(9)/l) and severe thrombocytopenia (platelet count50×10(9)/l). Risk factors for thrombocytopenia at birth were evaluated.Thrombocytopenia was present in 26% (94/362) of included neonates with HDFN at birth. Severe thrombocytopenia was found in 6% (20/362) of neonates. Three risk factors were found to be independently associated with thrombocytopenia at birth: treatment with intrauterine red cell transfusion (IUT) (OR 3·32, 95% CI 1·67-6·60, P=0·001), small for gestational age (SGA) below the 10th percentile (OR 3·32, 95% CI 1·25-8·80, P=0·016) and lower gestational age at birth (OR 1·22/week, 95% CI 1·02-1·44, P=0·025).Thrombocytopenia at birth occurs in 26% of neonates with HDFN due to red cell alloimmunization and is independently associated with IUT treatment, SGA and lower gestational age at birth. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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