[State of the liver antioxidant system and content of matrix metalloproteinase-2 of the large intestine under the effect of maleimide derivative in experimental colorectal carcinogenesis in rats]
| Autor: | O M, Filins'ka, S V, Iablons'ka, S Ia, Mandryk, I V, Kharchuk, H V, Ostrovs'ka, V K, Rybal'chenko |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Glutathione Peroxidase Dose-Response Relationship Drug Molecular Structure Superoxide Dismutase Blotting Western Antineoplastic Agents Matrix Metalloproteinase Inhibitors Catalase Thiobarbituric Acid Reactive Substances Antioxidants 1 2-Dimethylhydrazine Rats Maleimides Oxidative Stress Liver Animals Matrix Metalloproteinase 2 Intestine Large Intestinal Mucosa Colorectal Neoplasms Glutathione Transferase |
| Zdroj: | Ukrains'kyi biokhimichnyi zhurnal (1999 ). 82(4) |
| Popis: | The maleimide derivative--1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2.5-dione (MI-1) with cytostatic activity did not cause substantial changes of liver antioxidant system and level of matrix metalloproteinase-2 in intestinal mucosa after chronic treatment (for 20 weeks). MI-1 did not cause significant changes in the content of thiobarbituric-active products and plasma membrane protein carbonyl groups in the rat liver. However activities of superoxide dismutase, glutathione peroxidase, and content of reduced glutathione were decreased in both doses--0.027 and 2.7 mg/kg. The level of matrix metalloproteinase-2 in intestinal mucosa was decreased just in maximum dose--2.7 mg/kg. The contents of thiobarbituric-active products, protein carbonyl groups, reduced glutathione, matrix metalloproteinase-2, activities of glutathione peroxidase and glutathione-S-transferase in the liver cells have increased in 1.2-dimethylhydrazine-induced colon cancer in rats. The activities of enzymes of the first line of antioxidant defense--superoxide dismutase and catalase were decreased to 40%. The maleimide derivative prevents development of oxidation stress and partially reduce them to control level. |
| Databáze: | OpenAIRE |
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