[The effect of puromycin, nalidixic acid, and cycloheximide acetylcholinesterase purified from Electrophorus electricus L]

Autor: A H, Nery da Matta, F, Raul, J, Torres da Matta, H, Nesralla-Lobão, C, Chagas
Jazyk: francouzština
Rok vydání: 1975
Předmět:
Zdroj: Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles. 281(10)
Popis: The action of puromycin, nalidixic acid and cycloheximide on acetylcholinesterase has been studied using an "electrophoretically pure" preparation. Results obtained show that these well known inhibitors of protein synthesis have an inhibitory effect on acetylcholinesterase activity. The inhibitory action exercised by puromycin and nalidixic acid is of a mixed inhibition type, similar to the one seen when decamethonium and d-tubocurarine are used as inhibitory agents. Cycloheximide acts in a non competitive way on the enzyme activity.
Databáze: OpenAIRE