Preliminary observations on interaction of 14C-metronidazole with macromolecules in vivo and in vitro

Autor:	M, Chacko, G B, Maru, S V, Bhide
Rok vydání:	1986
Předmět:	Mice Fetus Liver Pregnancy Metronidazole Microsomes Liver Animals Proteins Female Carbon Radioisotopes DNA Protein Binding
Zdroj:	Indian journal of physiology and pharmacology. 30(3)
ISSN:	0019-5499
Popis:	Preliminary studies on the in vivo and in vitro interactions of 14C-metronidazole with macromolecules showed that the agent or its metabolite(s) can interact with nucleic acids and proteins in vivo. In vitro studies suggest that in absence of DNA synthesis trace amount of metronidazole does bind to DNA/protein and addition of metabolic activation system (from mouse liver) generates more reactive species from metronidazole.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bb8d4d55d684576e0fb64ffc68d49a5f https://pubmed.ncbi.nlm.nih.gov/3557608 Zobrazit plný text záznamu