New insights in antigen processing and epitope selection: development of novel immunotherapeutic strategies for cancer, autoimmunity and infectious diseases

Autor:	A, Haque, J S, Blum
Rok vydání:	2006
Předmět:	CD4-Positive T-Lymphocytes Antigen Presentation Immunodominant Epitopes Transplantation Immunology Neoplasms Histocompatibility Antigens Class II Animals Antigen-Presenting Cells Humans Immunotherapy Infections Autoimmune Diseases
Zdroj:	Journal of biological regulators and homeostatic agents. 19(3-4)
ISSN:	0393-974X
Popis:	Current evidence suggests that MHC class II-restricted CD4+ T-cells play a crucial role in orchestrating host immune responses against cancer as well as autoimmune and infectious diseases. Antigens must be processed within endosomal and lysosomal compartments of antigen presenting cells (APC) before binding to MHC class II molecules for display to T-cells. Only a limited number of processed peptides termed immunodominant are selected for display by MHC class II molecules and prove capable of inducing strong T-cell responses. Thus processing reactions within APC are of central importance for the development of effective vaccines as they modulate the number of peptide: class II complexes by enhancing or disrupting epitope formation and display. Studies suggest that there are substantial gaps in our knowledge of how antigen processing and presentation by APC regulates epitope selection and immunodominance in disease situations. Here we describe new insights in antigen processing and epitope selection with relevance to immunotherapeutic strategies for cancer, autoimmunity and infectious diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bb8a097cb8c30f10360b005d7d29446a https://pubmed.ncbi.nlm.nih.gov/16602623 Zobrazit plný text záznamu