| Autor: |
R B, Pai, R M, Lalitha, S B, Pai, S V, Kumaraswamy, N, Lalitha, M K, Bhargava |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Experimental oncology. 31(2) |
| ISSN: |
1812-9269 |
| Popis: |
The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro: and clinical response to MTX therapy.A pilot study of in vitro: evaluation of MTX response of oral cancer cells from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro: data were correlated to the clinical outcome to MTX therapy.A positive correlation was observed between the effect of MTX on tumor cells in vitro: and clinical response for 7 out of 10 patients.Observations from the proof-of-principle pilot study suggests that oral cancer cells have intrinsically variable response to MTX. Confirmation of these findings with a larger cohort of patients could aid in the development of individualized therapies for this class of malignancy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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