VivaGel™ (SPL7013 Gel): A candidate dendrimer – microbicide for the prevention of HIV and HSV infection

Autor:	Rupp, Richard, Rosenthal, Susan L, Stanberry, Lawrence R
Jazyk:	angličtina
Rok vydání:	2007
Předmět:	Clinical Trials as Topic Dendrimers SPL7013 VivaGel™ Anti-Infective Agents Local Humans HIV Infections Herpes Simplex Polylysine Review dendrimer Antiviral Agents microbicide
Zdroj:	International Journal of Nanomedicine
ISSN:	1178-2013 1176-9114
Popis:	Microbicides are compounds that applied vaginally or rectally, protect the user from sexually transmitted infections. Although no commercial product is yet available, many candidates are under development. A leading candidate, VivaGel™ (SPL7013 Gel) is the product of nanotechnology. The active ingredient is SPL7013, a dendrimer that was designed specifically with HIV and HSV antiviral activity and human safety in mind. SPL7013 has demonstrated efficacy against human immunodeficiency virus and herpes simplex virus in in vitro and animal models. VivaGel™ appears to be well tolerated in both animals and humans. This review summarizes the studies of VivaGel™ and its active ingredient, SPL7013.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::bac42200f1b2610189caed5a7a8b7d39 http://europepmc.org/articles/PMC2676817 Zobrazit plný text záznamu