| Autor: |
D L, Slate, E B, Fraser-Smith, J D, Rosete, V R, Freitas, Y N, Kim, S M, Casey |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
In vivo (Athens, Greece). 7(6A) |
| ISSN: |
0258-851X |
| Popis: |
Co-administration of doxorubicin and verapamil in Alzet mini-osmotic pumps increased the survival of B6D2F1 mice bearing the multidrug-resistant P388/ADR leukemia. A range of doxorubicin and verapamil combinations was studied to define dose-dependent efficacy and toxicity. High doses of doxorubicin (10 mg/kg/day) and verapamil (150 mg/kg/day) could be administered alone without any effect on survival. However, combining high doses of these two agents resulted in host toxicity. Doxorubicin doses of 1 to 10 mg/kg/day in combination with verapamil at 25-100 mg/kg/day were found to improve survival compared with either agent alone. Combination therapy also improved the survival of mice bearing the drug-sensitive P388/0 leukemia when compared to anthracycline treatment alone. The efficacy of the mini-osmotic pump delivery protocol was compared with other regimens delivering the same total cumulative dose of doxorubicin via repeated i.p. injections. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
