Stability of an extemporaneously compounded cisapride suspension

Autor:	J R, Horn, G D, Anderson
Rok vydání:	1994
Předmět:	Cisapride Chemistry Pharmaceutical Temperature Buffers Hydrogen-Ion Concentration Propylene Glycol Antioxidants Sodium Bicarbonate Drug Stability Parasympathomimetics Piperidines Solubility Suspensions Propylene Glycols Humans Pharmaceutical Vehicles
Zdroj:	Clinical therapeutics. 16(2)
ISSN:	0149-2918
Popis:	The purpose of the study was to formulate a cisapride suspension that would be stable under usual storage conditions for 3 weeks. Cisapride is a new prokinetic agent that is available as a coated tablet; occasionally, however, patients require a liquid preparation of cisapride. Cisapride was formulated with propylene glycol to enhance its solubility. The suspension was buffered with sodium bicarbonate to produce a pH between 6.5 and 7.5. The formulation provided a cisapride suspension that was stable at room temperature for 3 weeks.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ba7c988d04e351e4bb61425f1280d651 https://pubmed.ncbi.nlm.nih.gov/8062312 Zobrazit plný text záznamu