Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma
| Autor: | C K, Martin, W P, Dirksen, M M, Carlton, L G, Lanigan, S P, Pillai, J L, Werbeck, J K, Simmons, B E, Hildreth, C A, London, R E, Toribio, T J, Rosol |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Thiazines Mice Nude Bone Neoplasms Cat Diseases Meloxicam Real-Time Polymerase Chain Reaction Zoledronic Acid Article Mice Random Allocation Cell Line Tumor Antineoplastic Combined Chemotherapy Protocols Animals Humans Cyclooxygenase Inhibitors Neoplasms Squamous Cell RNA Messenger Bone Resorption Analysis of Variance Bone Density Conservation Agents Diphosphonates Imidazoles stomatognathic diseases Disease Models Animal Thiazoles Treatment Outcome Cyclooxygenase 2 Cats Cyclooxygenase 1 Heterografts Mouth Neoplasms |
| Zdroj: | Veterinary and comparative oncology. 13(3) |
| ISSN: | 1476-5829 |
| Popis: | Oral squamous cell carcinoma is common in cats and humans and invades oral bone. We hypothesized that the cyclooxygenase-2 inhibitor, meloxicam, with the bisphosphonate, zoledronic acid (ZOL), would inhibit tumor growth, osteolysis and invasion in feline oral squamous cell carcinoma (OSCC) xenografts in mice. Human and feline OSCC cell lines expressed cyclooxygenase (COX)-1 and 2 and the SCCF2 cells had increased COX-2 mRNA expression with bone conditioned medium. Luciferase-expressing feline SCCF2Luc cells were injected beneath the perimaxillary gingiva and mice were treated with 0.1 mg/kg ZOL twice weekly, 0.3 mg/kg meloxicam daily, combined ZOL and meloxicam, or vehicle. ZOL inhibited osteoclastic bone resorption at the tumor-bone interface. Meloxicam was more effective than ZOL at reducing xenograft growth but did not affect osteoclastic bone resorption. Although a synergistic effect of combined ZOL and meloxicam was not observed, combination therapy was well tolerated and may be useful in the clinical management of bone-invasive feline OSCC. |
| Databáze: | OpenAIRE |
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