Relationships Between Forced Oscillatory Impedance and 6-minute Walk Distance After Pulmonary Rehabilitation in COPD
Autor: | Sabine C, Zimmermann, Cindy, Thamrin, Andrew Sl, Chan, Amy, Bertolin, David G, Chapman, Gregory G, King |
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Rok vydání: | 2019 |
Předmět: |
Male
Time Factors Vital Capacity Pilot Projects Walk Test Pulmonary Disease Chronic Obstructive Predictive Value of Tests Forced Expiratory Volume Oscillometry Humans COPD Prospective Studies Lung Aged Original Research Aged 80 and over Exercise Tolerance six-minute walk test reactance Recovery of Function pulmonary rehabilitation Respiratory Function Tests forced oscillation technique Treatment Outcome quality of life Female |
Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
ISSN: | 1178-2005 |
Popis: | Rationale Pulmonary rehabilitation for chronic obstructive pulmonary disease (COPD) reduces dyspnoea and improves exercise capacity and quality of life. The improvement in exercise capacity is variable and unpredictable, however. Respiratory system impedance obtained by forced oscillation technique (FOT) as a measure of ventilatory impairment in COPD may relate to improvement in exercise capacity with pulmonary rehabilitation. We aimed to determine if baseline FOT parameters relate to changes in exercise capacity following pulmonary rehabilitation. Methods At the start of rehabilitation, 15 COPD subjects (mean(SD) 75.2(6.1) years, FEV1 z-score −2.61(0.84)) had measurements by FOT, spirometry, plethysmographic lung volumes and 6-minute walk distance (6MWD). Respiratory system resistance (Rrs) and reactance (Xrs) parameters as the mean over all breaths (Rmean, Xmean), during inspiration only (Rinsp, Xinsp), and expiratory flow limitation (DeltaXrs = Xinsp−Xexp), were calculated. FOT and 6MWD measurements were repeated at completion of rehabilitation and 3 months after completion. Results At baseline, Xrs measures were unrelated to 6MWD. Xinsp improved significantly with rehabilitation (from mean(SD) −2.35(1.02) to −2.04(0.85) cmH2O.s.L−1, p=0.008), while other FOT parameters did not. No FOT parameters related to the change in 6MWD at program completion. Baseline Xmean, DeltaXrs, and FVC z-score correlated with the change in 6MWD between completion and 3 months after completion of rehabilitation (rs=0.62, p=0.03; rs=−0.65, p=0.02; and rs=0.62, p=0.03, respectively); with worse ventilatory impairment predicting loss of 6MWD. There were no relationships between Rrs parameters, FEV1 or FEV1/FVC z-scores and changes in 6MWD. Conclusion Baseline reactance parameters may be helpful in predicting those patients with COPD at most risk of loss of exercise capacity following completion of pulmonary rehabilitation. |
Databáze: | OpenAIRE |
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