| Autor: |
V A, Proïnova, G N, Pershin, L F, Shashkina, M I, Golubeva |
| Rok vydání: |
1978 |
| Předmět: |
|
| Zdroj: |
Farmakologiia i toksikologiia. 41(1) |
| ISSN: |
0014-8318 |
| Popis: |
Results of testing the embryotropic activity of bonaphthone used in different doses (700; 400; 100; 50 and 2 mg/kg) are reported. With its oral introduction to pregnant rats bonaphthone, given in doses at the level of the therapeutid one (2 mg/kg) and exceeding it by as much as 25 times (50 mg/kg), was found not to produce any damaging effect on the fetus. With its action in doses of 100 and 400 mg/kg a slight embryotoxic effect was noted. In the sublethal dose of 700 mg/kg the preparation displays a moderate embryotoxic action and produces a number of circulatory changes in the fetuses. It is concluded that bonaphthone displays no teratogenic properties. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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