Identification of a gene encoding a human oxysterol-binding protein-homologue: a potential general molecular marker for blood dissemination of solid tumors
| Autor: | M V, Fournier, F, Guimarães da Costa, M E, Paschoal, L V, Ronco, M G, Carvalho, A B, Pardee, F C, Giumaraes |
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| Rok vydání: | 1999 |
| Předmět: |
Receptors
Steroid Lung Neoplasms Papillomavirus E7 Proteins Molecular Sequence Data Breast Neoplasms Biomarkers Tumor Humans Amino Acid Sequence Breast RNA Messenger RNA Neoplasm Neoplasm Metastasis Papillomaviridae Cells Cultured Cell Line Transformed Sequence Homology Amino Acid Reverse Transcriptase Polymerase Chain Reaction Epithelial Cells Oncogene Proteins Viral Neoplastic Cells Circulating Gene Expression Regulation Neoplastic Repressor Proteins Genes Colonic Neoplasms Disease Progression Sequence Alignment HeLa Cells |
| Zdroj: | Cancer research. 59(15) |
| ISSN: | 0008-5472 |
| Popis: | This study describes a new potential role in human cancer for a gene, HLM, isolated by differential display, that bears homology to an oxysterol-binding protein. A significant association between increased expression of HLM with metastatic disease was found. HLM mRNA levels were increased in circulating tumor cells in patients' peripheral blood and in primary human epithelial cells expressing the human papillomavirus16 E6 and E7 proteins. HLM mRNA was not detected in most normal human tissues, including peripheral blood and lymph node. These findings indicate that HLM may function as a potential marker for tumor dissemination. |
| Databáze: | OpenAIRE |
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