Induced production of nitric oxide and sensitivity of alveolar macrophages derived from mice with different sensitivity to Coxiella burnetii

Autor:	K, Yoshiie, S, Matayoshi, T, Fujimura, N, Maeno, H, Oda
Rok vydání:	2000
Předmět:	Nitroprusside Mice Inbred BALB C Mice Inbred A Chick Embryo Nitric Oxide Immunity Innate Cell Line Mice Inbred C57BL Mice NG-Nitroarginine Methyl Ester Coxiella burnetii Macrophages Alveolar Animals Disease Susceptibility Enzyme Inhibitors Nitric Oxide Synthase Q Fever Cells Cultured
Zdroj:	Acta virologica. 43(5)
ISSN:	0001-723X
Popis:	We compared in vitro sensitivities to Coxiella burnetii of alveolar macrophages, derived from mice sensitive and resistant to C. burnetii, respectively, and examined the role of nitric oxide (NO) in the C. burnetii infection. Alveolar macrophages of sensitive A/J mice showed a larger population of C. burnetii antigen-positive cells than those of resistant C57BL/6 mice. C. burnetii induced NO production in alveolar macrophages, but N-methyl-L-arginine and sodium nitroprusside (SNP), NO inhibitor and donor, respectively, did not inhibit the infection. Thus the NO induction seems to be independent of the cell defense mechanism against the C. burnetii infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ba0fe316a4da8d0e8cbf6babc7b80595 https://pubmed.ncbi.nlm.nih.gov/10757226 Zobrazit plný text záznamu