Use of the SL-IV and the PGL-Tb1 glycolipid antigens in ELISA for the diagnosis of tuberculosis in AIDS patients

Autor:	H C, Berlie, J C, Petit, H L, David
Rok vydání:	1991
Předmět:	Acquired Immunodeficiency Syndrome Antigens Bacterial Predictive Value of Tests Humans Tuberculosis Enzyme-Linked Immunosorbent Assay Mycobacterium tuberculosis Cross Reactions Glycolipids Mycobacterium avium Complex Antibodies Bacterial Mycobacterium avium-intracellulare Infection
Zdroj:	Zentralblatt fur Bakteriologie : international journal of medical microbiology. 275(3)
ISSN:	0934-8840
Popis:	At a predetermined specificity of 100.0%, the sensitivity of ELISA using the PGL-Tb1 and SL-IV antigens and IgG assays was 35.0% for the diagnosis of tuberculosis in AIDS patients (44.1% when tuberculosis was diagnosed before AIDS, 21.7% when AIDS was diagnosed before tuberculosis). Serial assays in sera collected from 11 AIDS patients before tuberculosis was diagnosed indicated that significant antibody titres were detected 10 months before the onset of clinical tuberculosis. Consequently, it was proposed that serodiagnosis using the glycolipid specific antigens should help in deciding on preventive antituberculosis treatment in these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ba0b27f3febad738aeefecbde9710cd4 https://pubmed.ncbi.nlm.nih.gov/1741916 Zobrazit plný text záznamu