| Autor: |
O G, Ogloblina, V V, Ruanet, O V, Kazakova, T S, Paskhina, V N, Orekhovich |
| Rok vydání: |
1980 |
| Předmět: |
|
| Zdroj: |
Biokhimiia (Moscow, Russia). 45(12) |
| ISSN: |
0320-9725 |
| Popis: |
The kininogenase activity of highly purified preparations of cathepsins D from human liver and spleen, leukemic infiltrate obtained from patients with myeloic leukemia, and from chicken liver was studied. It was found that pepstatin, a specific inhibitor of carboxylic proteinases, inhibits this activity of cathepsins D. Interaction of chicken liver cathepsin D with human plasma substrate, which is possibly a low molecular weight kininogen (Ks = 1.3.10(-7) M) results in a production of the bradikinin analog methionyl-lysyl-bradikinin. The role of cathepsins D as potent inflammatory agents responsible for the generation of biologically active peptides--mediators of inflammation from the protein substrates including kininogens under desintegration of lysosomes is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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