| Autor: |
Emanuela, Roscetto, Rosa, Bellavita, Rossella, Paolillo, Francesco, Merlino, Nicola, Molfetta, Paolo, Grieco, Elisabetta, Buommino, Maria Rosaria, Catania |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Antibiotics |
| ISSN: |
2079-6382 |
| Popis: |
Over the years, the increasing acquisition of antibiotic resistance genes has led to the emergence of highly resistant bacterial strains and the loss of standard antibiotics’ efficacy, including β-lactam/β-lactamase inhibitor combinations and the last line carbapenems. Klebsiella pneumoniae is considered one of the major exponents of a group of multidrug-resistant ESKAPE pathogens responsible for serious healthcare-associated infections. In this study, we proved the antimicrobial activity of two analogues of Temporin L against twenty carbapenemase-producing K. pneumoniae clinical isolates. According to the antibiotic susceptibility assay, all the K. pneumoniae strains were resistant to at least one other class of antibiotics, in addition to beta-lactams. Peptides 1B and C showed activity on all test strains, but the lipidated analogue C expressed the greater antimicrobial properties, with MIC values ranging from 6.25 to 25 µM. Furthermore, the peptide C showed bactericidal activity at MIC values. The results clearly highlight the great potential of antimicrobial peptides both as a new treatment option for difficult-to-treat infections and as a new strategy of drug-resistance control. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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