| Autor: |
Robert, Koralewski, Barbara, Dymek, Marzena, Mazur, Piotr, Sklepkiewicz, Sylwia, Olejniczak, Wojciech, Czestkowski, Krzysztof, Matyszewski, Gleb, Andryianau, Piotr, Niedziejko, Michal, Kowalski, Mariusz, Gruza, Bartłomiej, Borek, Karol, Jedrzejczak, Agnieszka, Bartoszewicz, Elżbieta, Pluta, Aleksandra, Rymaszewska, Magdalena, Kania, Tomasz, Rejczak, Sylwia, Piasecka, Michal, Mlacki, Marcin, Mazurkiewicz, Michał, Piotrowicz, Magdalena, Salamon, Agnieszka, Zagozdzon, Agnieszka, Napiorkowska-Gromadzka, Aneta, Bartlomiejczak, Witold, Mozga, Paweł, Dobrzański, Karolina, Dzwonek, Jakub, Golab, Marcin, Nowotny, Jacek, Olczak, Adam, Golebiowski |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of medicinal chemistry. 63(24) |
| ISSN: |
1520-4804 |
| Popis: |
Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase) are the enzymatically active chitinases that have been implicated in the pathology of chronic lung diseases such as asthma and interstitial lung diseases (ILDs), including idiopathic pulmonary fibrosis (IPF) and sarcoidosis. The clinical and preclinical data suggest that pharmacological inhibition of CHIT1 might represent a novel therapeutic approach in IPF. Structural modification of an advanced lead molecule |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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