| Autor: |
D G, Priest, J C, Schmitz, M A, Bunni |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Seminars in oncology. 26(2 Suppl 6) |
| ISSN: |
0093-7754 |
| Popis: |
The pharmacokinetics of folic acid, and resultant metabolites thereof, have been determined after administration orally and intravenously at 25 mg/m2 and 125 mg/m2. Saturation behavior was observed for uptake of folic acid into plasma and with regard to metabolism to methylenetetrahydrofolate and tetrahydrofolate as well as methyltetrahydrofolate. Repetitive oral administration every 6 hours resulted in consistently elevated levels of each metabolite pool with the same general saturation behavior as observed with single dose administration. This repetitive oral administration is concluded to be a suitable means to provide uniform elevation of metabolites that could offer protection from undesirable toxic effects of drugs such as MTA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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