| Autor: |
H, Rouibah, W, Kebsa, M, Lahouel, M, Zihlif, M, Ahram, B, Aburmaileh, M A, Mansour Al Shhab, H J, Al-Ameer, E, Mustafa |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 72(2) |
| ISSN: |
1899-1505 |
| Popis: |
Breast cancer is a common cancer and is the leading cause of cancer-related deaths among women worldwide. Studies have shown that breast cancer is a heterogeneous tumor with varying response to treatments. The clinical use of doxorubicin (Dox) in the treatment of cancer is limited by its cardiotoxicity which results in often fatal heart failure and the development of multidrug resistance. Therefore, new therapeutic strategies and targets are underscored. Propolis has been reported to show a broad spectrum of biological activities including anticancer activity. In this study, we investigated the role of propolis on the antitumor effects of Dox on breast cancer cells (MDA-MB-231) and its ability to provide protection against Dox-mediated damage on normal cells (MRC-5). Modifications in cell viability, apoptosis induction, cell cycle progression and permeability glycoprotein (P-gp) activity of breast cancer cells in vitro were evaluated. Propolis combined with Dox inhibited cell growth in a dose dependent manner by inducing cell cycle arrest in the S phase and caspase-dependent apoptosis. In the presence of propolis, the IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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