| Autor: |
M P, Potapnev, E P, Vashkevich, V P, Savitskiĭ, M V, Belevtsev, R S, Ismail-zade, N E, Konoplia |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Voprosy onkologii. 51(6) |
| ISSN: |
0507-3758 |
| Popis: |
In vitro experiments were conducted to determine the impact of interleukin-2 (IL-2) on apoptosis and function of cytostatic-cultured lymphoid (mononuclear) cells (MNC) of peripheral blood from healthy subjects and children with cancer. Neither slight or any effect on vepesid-16 or carboplatin--cultured MNC apoptosis, nor any phytohemagglutinin--induced proliferation was found. By contrast, in carboplatin- cultured MNC from healthy subjects, IL-2 significantly potentiated their toxicity for tumor cells by producing interferon-gamma. It was concluded that IL-2 predominantly supported MNC functional activity rather than inhibited lymphoid MNC apoptosis in in vitro culture with cytostatic drugs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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