Supplementation with
| Autor: | Maria Vittoria, Micioni Di Bonaventura, Maria Magdalena, Coman, Daniele, Tomassoni, Emanuela, Micioni Di Bonaventura, Luca, Botticelli, Maria Gabriella, Gabrielli, Gian Maria, Rossolini, Vincenzo, Di Pilato, Cinzia, Cecchini, Amedeo, Amedei, Stefania, Silvi, Maria Cristina, Verdenelli, Carlo, Cifani |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
DNA Bacterial Leptin Male 16S obesity food intake Adipose Tissue White Diet High-Fat Weight Gain Article Rats Sprague-Dawley Feces body weight RNA Ribosomal 16S Adipocytes microbiota Animals cafeteria (CAF) diet Probiotics Biodiversity Lactiplantibacillus (L.) plantarum IMC 510 Lipid Metabolism Animal Feed Gastrointestinal Microbiome Rats Lipoproteins LDL Disease Models Animal Liver Dietary Supplements |
| Zdroj: | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact of Lactiplantibacillus (L.) plantarum IMC 510 in a rat model of diet-induced obesity, specifically in the cafeteria (CAF) diet. This diet provides a strong motivation to voluntary overeat, due to the palatability and variety of selected energy-dense foods. The oral administration for 84 days of this probiotic strain, added to the CAF diet, decreased food intake and body weight gain. Accordingly, it ameliorated body mass index, liver and white adipose tissue weight, hepatic lipid accumulation, adipocyte size, serum parameters, including glycemia and low-density lipoprotein levels, in CAF fed rats, potentially through leptin control. In this scenario, L. plantarum IMC 510 showed also beneficial effects on GM, limiting the microbial imbalance established by long exposure to CAF diet and preserving the proportion of different bacterial taxa. Further research is necessary to better elucidate the relationship between GM and overweight and then the mechanism of action by which L. plantarum IMC 510 modifies weight. However, these promising results prompt a clear advantage of probiotic supplementation and identify a new potential probiotic as a novel and safe therapeutic approach in obesity prevention and management. |
| Databáze: | OpenAIRE |
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