Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery

Autor:	Philipp, Groene, Sophia R, Sappel, Thomas, Saller, Tobias, Nitschke, Paula A, Sa, Alexander, Paulus, Daniel, Chappell, Simon T, Schäfer
Rok vydání:	2020
Předmět:	Tranexamic Acid Blood Loss Surgical Humans Administration Intravenous Blood Transfusion Orthopedic Procedures Antifibrinolytic Agents
Zdroj:	Journal of thrombosis and thrombolysis. 51(4)
ISSN:	1573-742X
Popis:	Tranexamic acid (TXA) can reduce blood loss and transfusion rates in orthopaedic surgery. In this regard, a new viscoelastometric test (TPA-test, ClotPro), enables the monitoring of TXA effects. This prospective observational study evaluated and correlated TXA plasma concentrations (cTXA) following intravenous and oral administration in patients undergoing elective orthopaedic surgery with lysis variables of TPA-test. Blood samples of 42 patients were evaluated before TXA application and 2, 6, 12, 24 and 48 h afterwards. TPA-test was used to determine lysis time (LT) as well as maximum lysis (ML) and cTXA was measured using Ultra-High-Performance-Liquid-Chromatography/Mass-Spectrometry. Data are presented as median (min-max). LT
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b8f3e27338009e36935ba4b8bca738e6 https://pubmed.ncbi.nlm.nih.gov/32918670 Zobrazit plný text záznamu Full text from SpringerLink