CLN-3 protein is expressed in the pancreatic somatostatin-secreting delta cells

Autor:	R L, Boriack, M J, Bennett
Rok vydání:	2001
Předmět:	Somatostatin-Secreting Cells Membrane Glycoproteins Proteins Immunohistochemistry Antibodies Epitopes Neuronal Ceroid-Lipofuscinoses Protein Biosynthesis Animals Humans Rabbits Child Somatostatin Molecular Chaperones
Zdroj:	European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 5
ISSN:	1090-3798
Popis:	Juvenile neuronal ceroid lipofuscinosis (JNCL) is a severe autosomal recessive neurodegenerative disorder resulting from mutations in the CLN3 gene. The gene product is a 438-amino acid hydrophobic peptide of unknown function containing five transmembrane domains. In order to study the tissue distribution of the peptide, polyclonal antibodies were raised in rabbits to three epitopes and were affinity purified before use. All three antibodies were used together for immunocytochemical staining of human pancreas. This staining showed localization in pancreatic islet cells. Double labelling of the tissue indicated that cells staining for the CLN3 protein were also positive for somatostatin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b8e871c7dfc57685316132210a1c6232 https://pubmed.ncbi.nlm.nih.gov/11589017 Zobrazit plný text záznamu Full Text from ScienceDirect