| Autor: |
K M, Zangwill, A, Schuchat, F X, Riedo, R W, Pinner, D T, Koo, M W, Reeves, J D, Wenger |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
JAMA. 277(5) |
| ISSN: |
0098-7484 |
| Popis: |
To evaluate the epidemiologic features and risk factors for multiple cases of meningococcal disease in schools.Population-based prospective evaluation and case-control study of clusters of meningococcal disease that occurred in schools from January 1989 to June 1994.Surveillance conducted through state health departments in the United States.Descriptive epidemiology of school-based clusters of meningococcal disease and determinants of their occurrence.We identified 22 clusters of meningococcal disease in 15 states. The estimated incidence of secondary meningococcal disease among schoolchildren aged 5 to 18 years was 2.5 per 100000 population, a relative risk of 2.3 (95% confidence interval [CI], 1.6-3.3). The median number of students per cluster was 2 (range, 2-4). Of 30 subsequent cases, 10 (33%) occurred 2 or fewer days after the index case, and 22 (73%) occurred 14 or fewer days after the index case. Among the 8 schools with 2 or more cases, 50% of the additional cases occurred 2 or more days after the second case. Secondary schools (grades 7 through 12) accounted for 15 (75%) of 20 cluster schools compared with 9 (45%) of 20 matched control schools (P.05). In 16 (73%) of 22 clusters, interaction between case patients was noted. The index patient in cluster schools was more likely than the controls to have participated in a school-based group activity 14 or fewer days before illness (matched odds ratio, 7.0; 95% CI, 0.9-57).Three quarters of the school clusters occurred in secondary schools, with over 70% of subsequent cases occurring within 2 weeks of the index case. Rapid initiation of a chemoprophylaxis program after 2 cases of meningococcal disease in a school would have potentially prevented 50% of subsequent cases in the clusters described. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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