| Autor: |
R M, Hostetler, J, Reinhard, G R, Peterson |
| Rok vydání: |
1976 |
| Předmět: |
|
| Zdroj: |
Research communications in chemical pathology and pharmacology. 15(1) |
| ISSN: |
0034-5164 |
| Popis: |
Five different strains of mice were investigated for their suitability to serve as models for the study of long-term effects of propoxyphene napsylate (PN) on narcotic-dependent mice. The NIH/Swiss outbred strain proved to be most suitable because of its high liability to manifest physical dependence on morphine. Following removal of subcutaneously-implanted morphine pellets from the mice, the incidence of spontaneous withdrawal jumping was used as a quantifiable criterion of physical dependence. An orally administered suspension of PN suppressed the withdrawal jumping in a dose-dependent manner. However, chronic (daily) administration of PN at doses high enough to prevent withdrawal jumping was characterized by a high degree of toxicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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