GTP (gammaS) and GDP (betaS) as electron donors: new wine in old bottles

Autor:	D A, Peterson, D C, Peterson, H L, Reeve, S L, Archer, E K, Weir
Rok vydání:	1999
Předmět:	Dose-Response Relationship Drug Guanosine 5'-O-(3-Thiotriphosphate) Cytochrome c Group Dithionitrobenzoic Acid Thionucleotides Guanosine Diphosphate Oxidation-Reduction
Zdroj:	Life sciences. 65(11)
ISSN:	0024-3205
Popis:	G proteins are membrane-bound regulatory proteins which modulate the activity of ion channels and other effector systems. The GTP and GDP analogs GTP (gammaS) and GDP (betaS) have been used to study the role of G proteins in numerous physiologic systems. The prolonged effects of these analogs have been thought to be due to the fact that they are nonhydrolyzable. However, in this paper we show that the GTP (gammaS) and GDP (betaS) analogs are potent reducing agents at physiologic pH. This observation suggests that previous data obtained using these compounds may need to be reinterpreted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b8afde0337dc26c623b3ee58a18dce62 https://pubmed.ncbi.nlm.nih.gov/10503929 Zobrazit plný text záznamu Full Text from ScienceDirect