COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung. A study of 117 patients from Brazil
| Autor: | Nise H, Yamaguchi, Ana J, Lichtenfels, Lea M, Demarchi, Alecsander P, da Silva, Ana L, Garippo, Venancio F, Alves, Carolina, Michelin, Pedro M, Azevedo, Tatiana, Moya, Tereza, Takagaki, Paulo H, Saldiva, Robin T, Vollmer, Vera L, Capelozzi |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Aged 80 and over Male Lung Neoplasms Membrane Proteins Adenocarcinoma Middle Aged Survival Analysis Disease-Free Survival Immunoenzyme Techniques Isoenzymes Survival Rate Matrix Metalloproteinase 9 Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Biomarkers Tumor Humans Female Brazil Aged Neoplasm Staging Proportional Hazards Models |
| Zdroj: | American journal of clinical pathology. 121(1) |
| ISSN: | 0002-9173 |
| Popis: | We report immunohistochemical staining results for cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 in primary tumors of 117 patients with resected adenocarcinoma of the lung (median follow-up, 20 months). For COX-2, we graded the degree of tumor staining according to the sum of staining intensity and the proportion of cells staining. For MMP-9, we used morphometry to quantify cytoplasmic staining. We used the Cox proportional hazards model to analyze overall survival. With only 29 patients censored at last follow-up, after controlling for the effect of pathologic stage, staining for COX-2 and MMP-9 and subtype of tumor were related significantly to survival (P6 x 10(-5)). The effects of COX-2 and MMP-9 were opposite. Whereas any staining for COX-2 decreased the hazard and increased survival time, increased staining for MMP-9 increased the hazard and decreased survival time. The results also suggested that staining for COX-2 decreases with dedifferentiation. Our results suggest that staining for the combination of COX-2 and MMP-9 and categorizing tumors into papillary and nonpapillary types may provide important prognostic information for patients with resected adenocarcinoma of the lung; it is possible that these 3 variables could aid decisions about postoperative adjuvant treatment. |
| Databáze: | OpenAIRE |
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