Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP
| Autor: | Jiahong, Zhong, Jinfeng, Xie, Jiao, Xiao, Dan, Li, Bingtian, Xu, Xinyi, Wang, Huizhen, Wen, Zhongzhen, Zhou, Yufang, Cheng, Jiangping, Xu, Haitao, Wang |
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| Rok vydání: | 2018 |
| Předmět: |
Neurons
Primary Cell Culture RNA-Binding Proteins Parkinson Disease Neuroprotection Cyclic Nucleotide Phosphodiesterases Type 4 Mice Oxidative Stress AMP-Activated Protein Kinase Kinases Gene Expression Regulation Benzamides Autophagy Animals Humans Phosphodiesterase 4 Inhibitors Reactive Oxygen Species Microtubule-Associated Proteins Protein Kinases |
| Zdroj: | Free radical biologymedicine. 135 |
| ISSN: | 1873-4596 |
| Popis: | The etiology of Parkinson's disease (PD) is generally not well understood, but it is believed to involve excessive oxidative insult. Hence, identifying therapeutic targets and compounds that exhibit protective effects against oxidative damage is a reasonable strategy to slow down the progression of PD. FCPR16 is a novel phosphodiesterase 4 inhibitor with little emetic potential. Our previous studies showed that FCPR16 was able to block 1-Methyl-4-phenylpyridine (MPP |
| Databáze: | OpenAIRE |
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