Localization of the human membrane-type 2 matrix metalloproteinase gene (MMP15) to 16q12.1 near DNA elements that are part of centromeric and non-centromeric heterochromatin of 11 human chromosomes

Autor:	M R, Koehler, C G, Sauer, N, Reismann, C, Steinlein, B H, Weber, H, Will, M, Schmid
Rok vydání:	1998
Předmět:	Matrix Metalloproteinases Membrane-Associated Heterochromatin Karyotyping Molecular Sequence Data Chromosome Mapping Humans Matrix Metalloproteinase 15 Metalloendopeptidases Chromosomes Human Pair 16 In Situ Hybridization Fluorescence Metaphase
Zdroj:	Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 6(3)
ISSN:	0967-3849
Popis:	We have localized a second gene for membrane-type matrix metalloproteinases, MT2-MMP, to chromosome 16q12 by in situ hybridization. FISH experiments using a genomic PAC clone containing the MT2-MMP gene resulted in an unusual hybridization pattern detecting centromeric and non-centromeric heterochromatin regions or its flanking sequences in 11 human chromosomes in addition to the MT2-MMP locus on chromosome 16q12. The detailed analysis of this hybridization pattern using molecular cytogenetic methods together with the specific hybridization of the MT2-MMP cDNA allowed a refined mapping of the gene to 16q12.1, directly adjacent to the 16q heterochromatin. Our findings may give some insights into the evolution of the MMP gene family.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b8867cb36cc71d15615b4be77ad46f0a https://pubmed.ncbi.nlm.nih.gov/9609663 Zobrazit plný text záznamu Full text from SpringerLink