The Effect of Elapsed Time from Myocardial Infarction on Mortality and Major Adverse Cardiac and Cerebrovascular Events in ICD Patients

Autor:	Lidia R, Bons, Lara, Dabiri-Abkenari, Ron T, VAN Domburg, Tamas, Szili-Torok, Felix, Zijlstra, Dominic A M J, Theuns
Rok vydání:	2015
Předmět:	Male Time Factors Myocardial Infarction Reproducibility of Results Comorbidity Middle Aged Sensitivity and Specificity Defibrillators Implantable Survival Rate Cerebrovascular Disorders Ventricular Dysfunction Left Death Sudden Cardiac Risk Factors Prevalence Humans Female Longitudinal Studies Aged Follow-Up Studies Netherlands
Zdroj:	Pacing and clinical electrophysiology : PACE. 38(12)
ISSN:	1540-8159
Popis:	Despite the effectiveness of implantable cardioverter defibrillator (ICD) therapy in reducing mortality, the optimal timing of ICD implantation after myocardial infarction (MI) remains inconclusive. The aim of this study is to evaluate the association of elapsed time from MI to ICD implantation on mortality and major adverse cardiac and cerebrovascular events (MACCEs) in patients with prior MI.We studied 974 patients who underwent a first ICD implantation between October 1998 and August 2011. The median time from MI to ICD implantation was 7.2 years. Elapsed time from MI to ICD was categorized into tertiles (2.5 years, 2.5-12.1 years,12.1 years). Additionally, the time from most recent MI to ICD implantation was dichotomized at 18 months.During a median follow-up of 3.4 years, 287 patients died. Cumulative mortality rates at 3 years, 5 years, and 8 years were 19%, 29%, 47%, respectively. In univariate analysis, there was a significant difference in mortality for patients in the highest tertile compared to those in the lowest tertile (hazard ratio: 1.50; 95% confidence interval: 1.12-2.02; P = 0.007). After adjusting for baseline characteristics, there was no association between time from MI and mortality. At 8-year follow-up, the cumulative MACCE rate excluding mortality was 22%. No association between time from MI and MACCE was found.In this study, we found no association between the elapsed time from MI to ICD implantation and 8-year all-cause mortality or MACCE in post-MI ICD patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b86bba255a9b2cc2f10e7fcb13815075 https://pubmed.ncbi.nlm.nih.gov/26289034 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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