The expression of cytochrome P-450, epoxide hydrolase, and glutathione S-transferase in hepatocellular carcinoma
| Autor: | G I, Murray, P J, Paterson, R J, Weaver, S W, Ewen, W T, Melvin, M D, Burke |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Aged 80 and over Epoxide Hydrolases Male Carcinoma Hepatocellular Liver Neoplasms Oxidoreductases N-Demethylating Middle Aged Cytosol Cytochrome P-450 Enzyme System Liver Cytochrome P-450 CYP1A1 Microsomes Liver Cytochrome P-450 CYP3A Humans Female Aryl Hydrocarbon Hydroxylases Oxidoreductases Aged Glutathione Transferase |
| Zdroj: | Cancer. 71(1) |
| ISSN: | 0008-543X |
| Popis: | Cytochrome P-450, epoxide hydrolase, and glutathione S-transferase (GST) all play a key role in the metabolism of chemical carcinogens, mutagens, and various anti-cancer drugs. All these functionally associated enzymes might be involved in both the development of hepatocellular carcinoma and in determining the anti-cancer drug sensitivity of such tumors.The expression of two forms of cytochrome P-450 (P-450 IA and P-450 IIIA), microsomal epoxide hydrolase, and three classes of cytosolic GST (alpha, mu, and pi) have been studied immunohistochemically in human hepatocellular carcinoma.The hepatocellular carcinomas were characterized by a consistently high expression of epoxide hydrolase and variable expression of the cytochromes P-450 and GST. Cytochrome P-450 IA and IIIA stained in 64.5% and 41.9% of the 31 hepatocellular carcinomas studied, respectively. Epoxide hydrolase was present in all tumors, and GST types alpha, pi, and mu were identified in 48.4%, 38.7%, and 74.2% of the hepatocellular carcinomas, respectively.This study showed that the expression of xenobiotic-metabolizing enzymes in hepatocellular carcinoma is complex and the presence of different xenobiotic enzymes in hepatocellular carcinoma may contribute to the intrinsic drug resistance of these tumors. |
| Databáze: | OpenAIRE |
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