Relapse of herpes simplex encephalitis after conventional acyclovir therapy

Autor: K E, VanLandingham, H B, Marsteller, G W, Ross, F G, Hayden
Rok vydání: 1988
Předmět:
Zdroj: JAMA. 259(7)
ISSN: 0098-7484
Popis: Acyclovir sodium is the drug of choice for the treatment of herpes simplex encephalitis. We treated an immunocompetent patient with a ten-day course of intravenous acyclovir sodium at the recommended dosage of 10 mg/kg every eight hours for clinically apparent herpes simplex encephalitis. After marked improvement, his condition deteriorated four days after completing acyclovir therapy. A subsequent brain biopsy specimen disclosed acyclovir-sensitive herpes simplex virus type 1. A longer duration of acyclovir therapy (14 to 21 days) should be considered for treating herpes simplex encephalitis.
Databáze: OpenAIRE