Differential galactose alpha(1,3) galactose expression by porcine cardiac vascular endothelium

Autor:	R H, Chen, R N, Mitchell, A, Kadner, D H, Adams
Rok vydání:	1999
Předmět:	Graft Rejection Epitopes Swine Transplantation Immunology Myocardium Transplantation Heterologous Animals Heart Transplantation Endothelium Vascular Disaccharides Coronary Vessels Immunohistochemistry
Zdroj:	Xenotransplantation. 6(3)
ISSN:	0908-665X
Popis:	Galactose alpha(1,3) galactose (Gal) is the terminal carbohydrate moiety recognized by xenoreactive natural antibodies during hyperacute rejection (HAR). Binding of these antibodies in HAR triggers rapid microvascular thrombosis. We examined the distribution of Gal on the endothelium of porcine hearts before and after heterotopic xenotransplantation into baboons. We found that Gal is strongly expressed on the endothelium of porcine capillaries with less expression on the endothelium of larger vessels. The distribution of Gal staining remains unchanged after xenotransplantation and correlates with the intensity of IgM and membrane attack complex (MAC) deposition. Thus, the Gal epitope is differentially expressed in the pig vasculature, which affects the pattern of xenoreactive antibody and MAC deposition and directs the distribution of vascular thrombosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b7f3f2775dadb8297332982c536a2d49 https://pubmed.ncbi.nlm.nih.gov/10503782 Zobrazit plný text záznamu Plný text