| Autor: |
Feng, Guo, Shanqing, Li, Chao, Guo, Xiaohui, Xu, Xiaoyun, Zhou, Dongjie, Ma, Zhili, Cao, Zhongxing, Bing, Yushang, Cui |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Am J Transl Res |
| ISSN: |
1943-8141 |
| Popis: |
The emerging roles of circular RNAs (circRNAs) in non-small cell lung cancer (NSCLC) have been convincingly proved. However, there are still numerous unknown circRNAs needing exploration. Here, present research performed a circRNA microarray analysis for the expression profile and identified a novel circRNA (circMAGI3, hsa_circ_0110498). Clinically, circMAGI3 was significantly up-regulated in NSCLC tissue and cells, which was closely correlated with unfavorable outcome for NSCLC patients. Functionally, circMAGI3 promoted the glycolysis and proliferation of NSCLC cells. Mechanistically, circMAGI3 functioned as a sponge for miR-515-5p to relieve its target gene HDGF expression, thereby accelerating the glycolysis of NSCLC. Collectively, this research identified the oncogenic role of circMAGI3 in the tumorigenesis through miR-515-5p/HDGF axis, providing a vital theoretical basis for treatment of NSCLC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
