| Autor: |
Weixin, Sun, Xiang, Wu, Peng, Yu, Qian, Zhang, Le, Shen, Jiandong, Chen, Huaqin, Tong, Manlu, Fan, Haibo, Shi, Xiaohu, Chen |
| Rok vydání: |
2021 |
| Zdroj: |
Frontiers in cell and developmental biology. 10 |
| ISSN: |
2296-634X |
| Popis: |
Ferroptosis is associated with the pathology of myocardial ischemia/reperfusion (MI/R) injury following myocardial infarction, which is a leading cause of death worldwide. Although long noncoding RNAs (lncRNAs) are known to regulate gene expression, their roles in MI/R-induced ferroptosis remain unclear. In this study, we explored the lncRNA expression profiles in a rat model of MI/R injury and found that the novel lncRNA, lncAABR07025387.1, was highly expressed in MI/R-injured myocardial tissues and hypoxia/reoxygenation (H/R)-challenged myocardial cells. Silencing lncAABR07025387.1 improved MI/R injury |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
